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    Sex‐based differences in the clinical presentation, pathophysiological mechanisms, and outcomes of chest pain patients are increasingly being recognized.

    Compared with men, women with an acute coronary syndrome (ACS) present more frequently with atypical chest pain complaints and a nondiagnostic ECG and less frequently with elevations of troponins.1, 2, 3, 4, 5, 6 Also, women are ≈10 years older and tend to have a higher risk factor burden than men when they experience their first cardiac event.3, 7 These differences may lead to a, possibly falsely, lower perceived risk of ACS in women than men presenting to the emergency department (ED) with chest pain.

    In past years, female‐specific attention for cardiovascular disease has emerged.

    The fact that women are under‐represented in clinical studies raises concerns regarding the evidence‐based preventive, diagnostic, and therapeutic options for women with cardiovascular disease.

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